MHLW Japan | CHUIKYO Drug Price calculations | iPharmaCenter

MHLW JAPAN | CHUIKYO DRUG PRICING | August 13, 2026

Brand INN Company Dosage	Indication	Calculated Drug Price	Calculation Method and premiums achieved
Juxtapid Capsules for Pediatric Use Lomitapide mesylate Recordati Rare Diseases 2mg per capsule	Homozygous familial hypercholesterolemia	¥72,127.50	Inter-standard adjustment Child surcharge = 5%,
Marvelon Desogestrel / Ethinylestradiol Organon 1 tablet	Dysmenorrhea	¥276.90	Similar drug efficacy comparison method (I) Usefulness premium (II) A=5%
Wayliv Tablets Rilzabrutinib Sanofi 400mg tablet	Persistent and chronic ITP	¥6,168.30	Similar drug efficacy comparison method (I) Usefulness premium (I) A=35% Marketability premium (I) A=10%
Cerdelga Eliglustat tartrate Sanofi 25mg per capsule	Gaucher's disease	¥25,023.10	Inter-standard adjustment Child surcharge = 5%
Joenja Leniolisib phosphate Orphan Pacific 10mg, 30mg, 70mg tablet	Activated PI3K delta syndrome	• 10mg: ¥27,077.90 • 30mg: ¥81,233.70 • 70mg: ¥189,545.30	Cost accounting method Usefulness bonus (I) A=40% Marketability premium (I) A=10% Pediatric Surcharge A=10%
Isotretinoin Capsules Isotretinoin Sun Pharma 8mg, 16mg capsule	Neuroblastoma post-high-dose chemotherapy	• 8mg: ¥507.90 • 16mg: ¥984.00	Similar drug efficacy comparison method (I) Usefulness premium (II) A=5% Marketability premium (II) A=20%
Xocova Ensitrelvir Fumaric acid Shionogi & Co 25mg tablet	SARS-CoV-2 infection	¥2,575.40	Inter-standard adjustment Child surcharge = 5%
Kineret Anakinra SOBI 100mg 0.67mL 1 tube	Systemic JIA, Adult-onset Still's disease	¥23,702.00	Cost calculation method Marketability premium (I) A=10% Child surcharge = 5%
Sarclisa Isatuximab Sanofi 1,400mg 10mL per vial	Multiple myeloma	¥270,495.00	Similar drug efficacy comparison method (I) Usefulness premium (II) A=5%
Rhopressa Netarsudil mesylate Santen Pharma 0.02% 1mL	Glaucoma	¥987.80	Similar drug efficacy comparison method (I) Usefulness premium (II) A=10%

Source: Adapted and translated from Ministry of Health, Labour and Welfare (MHLW) / Chuikyo drug pricing documentatio