GSK’s Jemperli received approval in Europe and the US for endometrial cancer

GSK has announced that the US FDA has approved Jemperli (dostarlimab), a programmed death receptor-1 (PD-1) for endometrial cancer.

The product was approved for adult patients with mismatch repair-deficient (dMMR) recurrent or advanced endometrial cancer.


Also read: Denmark Healthcare System



European Commission has also given conditional marketing authorization for women with mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) recurrent or advanced endometrial cancer. Jemperli is the first PD-L1 inhibitor approved for endometrial cancer.


Also read: Denmark Healthcare System


The approval by the European Commission and FDA was based on the GARNET study. GARNET is a multicentre, non-randomized, open-label study. Overall response rate and duration of response were considered as primary endpoints. The overall response rate was 42%, ≥six months duration of response was observed in 93% of patients.





The drug is administered as a 500 mg intravenous infusion every three weeks for four doses, followed by 1,000 mg administered every six weeks.


In the US, the product received the breakthrough designation in May 2019.


Also read: Denmark Healthcare System



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