The U.S. Food and Drug Administration has approved Nourianz (istradefylline) tablets for the treatment of adult patients with Parkinson’s disease. The drug is given in combination with levodopa/carbidopa during “off” periods. An “off” period is a time when the drugs don’t function, and the patients experience tremors and difficulty in walking.
Parkinson’s disease is the most common neurodegenerative disease after Alzheimer’s disease in the United States. The incidence of PD is 50,000/year. Cell producing the dopamine die or impair resulting in PD. The symptoms worsen gradually.
The efficacy was studied in four 12-week placebo-controlled studies involving 1,143 participants. In all the trials, patients experience significant “off” periods compared to the placebo-controlled studies.
The adverse events reported are involuntary muscle movement, dizziness, constipation, nausea, hallucination, and insomnia.
I was diagnosed with Parkinson’s disease a year ago at the age of 68. For several months I had noticed tremors in my right hand and the shaking of my right foot when I was sitting. My normally beautiful cursive writing was now small cramped printing. And I tended to lose my balance. Neurologist had me walk down the hall and said I didn’t swing my right arm. I had never noticed! I was in denial for a while as there is no history in my family of parents and five older siblings, but now accept I had classic symptoms. I was taking pramipexole (Sifrol), carbidopa/levodopa and Biperiden, 2 mg. and started physical therapy to strengthen muscles. nothin…
I was diagnosed with Parkinson’s disease a year ago at the age of 68. For several months I had noticed tremors in my right hand and the shaking of my right foot when I was sitting. My normally beautiful cursive writing was now small cramped printing. And I tended to lose my balance. Neurologist had me walk down the hall and said I didn’t swing my right arm. I had never noticed! I was in denial for a while as there is no history in my family of parents and five older siblings, but now accept I had classic symptoms. I was taking pramipexole (Sifrol), carbidopa/levodopa and Biperiden, 2 mg. and started physical therapy to strengthen muscles. nothin…
I am 65 years old, I was diagnosed of Parkinsons disease at the age of 59. I had severe calf pain, muscle pain, slurred speech, frequent falls, loss of balance, difficulty getting up from sitting position. I was placed on Sinemet 3 times daily, it helped me but not very much. My neurologist advised me to try natural treatments and introduced me to Rich Herbal Garden Parkinsons Disease Herbal formula, I read alot of positive reviews from other patients who used the treatment and i immediately started on the treatment. I had great improvement and relief with this treatment, total decline of symptoms. Great improvement with speech, co-ordination, balance, muscle, mood etc, I gained back my life with this treatment…