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Expected best selling pharmaceutical products (drugs) in 2021

Updated: Jun 27, 2023


Nature Reviews Drug Discovery and Evaluate Pharma published the 2021 sales forecast of best-selling drugs.

Humira is expected to remain the best-selling product, driving the sales of AbbVie. The product has been facing biosimilar competition in Europe, but the US market was primarily driving the sales. Nearly 80% of the Humira sales are being generated in the US, where the product will face biosimilar competition from 2023.

Merck’s Keytruda sales are expected to touch $16.8 billion. Keytruda, a PD-L1 inhibitor, is expected to have almost twice the revenues of Opdivo, another PD-L1 inhibitor. The product is approved for nearly 15 indications in the US, and the sales are primarily driven because of the lung cancer indication. The product is contributing to almost 30% of Merck’s revenues.

BMS obtained Revlimid with the acquisition of Celgene. The product is expected to add $12.71 billion to BMS in 2021. However, the product will face generic competition in the US market from 2022. The company has recently settled patent litigation with Cipla.

Eliquis, a product indicated for preventing stroke/systemic embolism in patients with NVAF and treatment of DVT/PE, is anticipated to forth the best-selling product in 2021.

Eylea, a product indicated for treating various eye diseases (wet age-related macular degeneration, visual impairment due to diabetic macular edema, and myopic choroidal neovascularization), might become the fifth best selling product in 2021. The product has higher sales than the Lucentis, a Roche product indicated for the same indications.

Opdivo, another PD-L1 inhibitor of BMS, is next on the list.

Janssen’s Stelara, a drug indicated for several immunological diseases, is expected to retain the seventh spot.

HIV product, Biktarvy expected to retain eight place on the list.

Imbruvica, the drug indicated for mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenström’s macroglobulinemia, is expected to add $7.6 billion to AbbVie’s revenue.

Xarelto is expected to be the tenth best selling product in 2021.

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1. Evaluate Vantage 2021 Preview

2. Nature Reviews Drug Discovery's Forecast of TOP 10 global best-selling drugs in 2021

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